الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
Summary and conclusion Cisplatin (CIS) is one of the most importan chemotherapeutic agents used to control several types of cancers. Despite its promising anti-cancer potential, CIS can adversely affect liver and kidney functions and induce testicular toxicity .it causes severe testicular damage through impairment of Leydig cell function and induction of germ cell apoptosis. Besides the DNA damage, excessive production of reactive oxygen species (ROS) is also implicated as one of the main causes of CIS-induced testicular damage.
Therefore, it is critical to prevent such side effects to preserve the fertilization capacity of patients who use CIS. Several antioxidants have been examined against CIS-induced testicular damage. Melatonin and MSCs derived exosomes offer the potential to open a new frontier in medicine.
This work was performed to evaluate the possible protective role of melatonin and exosomes derived from Mesenchymal stem cells gainst testicular toxicity caused by cisplatin.