الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 42 |  |  |
| | | from | 42 | | |
Abstract
1,2,4-Oxadiazoles are five-membered heterocyclic compounds containing one oxygen and two nitrogen
atoms (historically, they were also known as furadiazoles). Depending on the position of nitrogen atoms,
oxadiazoles may occur in the form of four different isomers: 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-
oxadiazole and 1,3,4-oxadiazole (Figure 1). Amongst the isomers, the greatest interest is involved with
1,3,4-oxadiazoles. Their high importance is highlighted by a large number of applications in various
scientific areas, e.g., pharmaceutical industry, drug discovery, scintillating materials as well as dyestuff
industry [1]. It is also worth noting that compounds containing 1,3,4-oxadiazole unit exhibit a wide range
of biological activities such as anticancer, antiparasitic, antifungal, antibacterial, antidepressant, antitubercular
and anti-inflammatory [2–5].In the last 40 years, 1,2,4-oxadiazole heterocycle has been widely
explored bringing a vast number of compounds exhibiting diverse biological activities such as anticancer,
anti-inflammatory, anticonvulsant, antiviral, antibacterial, antifungal, antidepressant, antiangiogenic,
analgesic, anti-insomnia, anti-oedema, antiparasitic, and anti-Alzheimer.