الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Alzheimer’s disease (AD) is the most common form of dementia in elderly people and is a progressive disease of the brain that leads to shrinkage of the brain tissue and irreversible loss of neurons. The aim of this study was to evaluate the effects of olive oil phenols on brain aging in rat and to verify whether the antioxidant and anti-inflammatory activities of these polyphenols were involved. Rat was fed from with extra-virgin olive oil (Coratina (C) and Koroneiki (K) olive oils (0.3 ml/kg of body weight/ day) and rich in phenols (total polyphenol dose/day, 0.16 mg/kg). Behavioral tests were employed to assess Object recognition test and Morris Water Maze apparatus in treated animals. Parameters of oxidative status and inflammation were measured in different brain areas at the same times and evaluated for correlation with behavioral changes. The present study was designed to evaluate the neuroprotective properties of olive oil in an aluminum chloride (AlCl3)-induced model of dementia in Wistar rats. Wistar rats were administered with dietary oils for 60 days before induction of Alzheimer’s disease (AD) using AlCl3. Spatial memory was assessed using Brain antioxidant parameters such as lactate dehydrogenase (LDH) activity malondialdehyde MDA levels (lipid peroxidation product) and nitrite levels were determined. In addition, tau protein and amyloid precursor amyloid precursor protein (APP) - Amyloid (β1-42) expression mRNA expression and the levels of acetylcholinesterase in serum biochemical.In addition, caspase-3 and tumor necrosis factor alpha (TNF-α) expression in brain tissue estimations were carried out. In conclusion, this work points out that natural polyphenols contained in extra-virgin olive oil can improve some age-related dysfunctions by differentially affecting different brain areas. Such a modulation can be obtained with an olive oil intake that is normal in the Mediterranean area, provided that the oil has a sufficiently high content of polyphenols.
Key words: Alzheimer’s disease, Amyloid β, tau protein, acetylcholinesterase, Morris Water Maze, TNFα, Phenolic compounds, Coratina, and koroneiki.