الفهرس 
Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Sepsis is a life-threatening illness caused by the body’s immune response to an infection that leads to multi-organ failure. Annually, there are 31.5 million sepsis cases, 19.4 million severe sepsis cases, and 5.3 million sepsis deaths estimated in high-income countries.
Studies have shown that early identification of sepsis following rapid initiation of antibiotic treatment improves patient outcomes and 6 h of treatment delay is shown to increase the mortality risk by 7.6%. Unfortunately, sepsis is commonly misdiagnosed and mistreated because deterioration with organ failure.
Recent studies have shown that cinnamon bark has high contents of bioactive compounds, including phenolic and polyphenolic compounds, with very important biological properties, such as antioxidant, antiinflammatory, and anti-microbial effects.
Cinnamon bark has been explored as a potential anti-inflammatory and anti-microbial candidate for inhibiting inflammatory pathway in the course of sepsis.
In this study, we hypothesized that cinnamon barke extract administration may be useful for amelioration of the cellular damage and inflammatory damage induced by sepsis and hence decreasing the incidence of sepsis and its fatal sequelae.
Materials and Methods:
The current study was conducted on seventy two healthy adult male Sprague-Dawley albino rats (each rat weighs 200-250 gm).
Twelve rats were used as donors for cecal slurry, and the others were divided into five experimental groups:
group I (Control group):
This group included 12 adult male albino rats that were divided into two subgroups (6 rats each):
Subgroup Ia (Plain control group):
The rats were kept without any treatment all over the experimental period.
Subgroup Ib (Sham control group):
The rats were injected intraperitoneally with 10ml/kg of 5% dextrose once.
group II (cinnamon bark extract treated group):
This group included 12 adult male albino rats. The rats were given cinnamon bark extract once daily orally by gastric intubation for 4 weeks and 5 days at a dose 100 mg /kg body weight /day dissolved in 1 ml distilled water.
group III (Experimentally induced septic group):
This group included 12 adult male albino rats. The rats were kept without any treatment for four weeks and 5 days then given inraperitoneal injection of 10 mL cecal slurry/kg body weight once. Scarification was done 48hours after sepsis induction.
group IV (cinnamon pretreated septic group):
This group included 12 adult male albino rats. The rats were given aqueous cinnamon extract once daily by gastric intubation at a dose of 100 mg/kg/day dissolved in 1 ml distalled water for 4 weeks and 5 days before the onset of sepsis induction by the same dose of cecal slurry mentioned in group III and was stopped immediately after sepsis induction.