الفهرس | Only 14 pages are availabe for public view |
Abstract SUMMARY Respiratory system affection is a major cause of morbidity and mortality in acute poisoned cases. The respiratory system is commonly affected in cases of acute poisoning due to poison action or its complications. Information on toxic acute respiratory distress (ARDS) is limited and the estimated incidence and mortality rates represent only a minute fraction of the true incidence. As in most drug-induced diseases, diagnosis is often difficult and is mostly based on exclusion of all other possible causes. Acute respiratory distress syndrome (ARDS) is an acute, diffuse inflammatory lung injury that leads to increase pulmonary vascular permeability, increase lung weight and loss of aerated tissue. Common poisons that cause respiratory system affection in acute state are phosphides, anti-cholinesterases, drug over dose as opioids and other central depressants like anti-psychotics, carbon monoxide, hydrocarbons, corrosives and animal bite particularly snake bite. Copeptin is a novel biomarker that could be used in differential diagnosis and risk evaluation of patients with acute dyspnea and stable in plasma and serum for at least 7 days in room temperature. Our study aimed to evaluate the prognostic value of Copeptin level and sequential organ failure assessment (SOFA) score as predictors in toxin linked acute respiratory distress syndrome in poisoned patients. This cohort prospective study conducted on patients of both sexes with toxin linked acute respiratory distress admitted to Tanta University Poison Control Center (TUPCC) , following approval of medical research ethical committee of Faculty of Medicine,Tanta University |