الفهرس 
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Abstract
Aim: The present study was conducted to evaluate the EZH2 expression in the typical and atypical warthin’s tumors (WTs) in comparison to mucoepidermoid carcinoma (MEC).Material and methods: The current retrospective study was conducted on 35 paraffin blocks retrieved from the archives of the Oncology Center, Mansoura University. This number was distributed among two main groups; WT (20 blocks) and MEC group (15 blocks). The WT group was designed to equally involve histologically typical and atypical subgroups. For the MEC, the three histologic grades were selected to be equally represented in this group. Sections of four microns’ thickness were serially cut and prepared for the IHC staining. Chi-square, Monte Carlo, and Fisher Exact tests were used for statistical analysis of the results.Results: It was found that the immunoreactivity for the EZH2 was significantly higher in MEC (73.3%) than in atypical WTs (50%) and typical WTs (20%) (p < 0.05). However, the difference between the EZH2 expression in the two subgroups of WT was not statistically significant. Although the immunoreaction for EZH2 in MEC was directly associated with tumor grade, yet it was not statistically significant (p > 0.05). Also, a statistically significant higher score of EZH2 expression was found among the older age groups (p < 0.05).Conclusion: It was concluded that EZH2 expression is a possible sensitive biomarker that might be able to unravel the subtle microscopic malignant epithelial changes that might be skipped during routine examination. The significant direct association between EZH2 expression and age group confirmed the sensitivity of EZH2 as a predictor of aggressive biologic behaviour in MEC. However, further follow up studies on larger sample size are recommended to confirm the possible prognostic role of EZH2 in MEC and suspicious WTs.