الفهرس 
Evaluation of caries preventive potential of preventive regimens containing herbal-based or fluoride-based toothpastes versus fluoride varnish and fluoride toothpaste only in High Caries Risk Patients: Randomized Clinical Trial
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Abstract
This study was conducted to assess the caries preventive effect of different preventive regimens using herbal toothpaste compared to fluoride varnish and fluoride toothpaste on the caries risk level of high caries risk patients.
Material and methods: The study design was three-armed, parallel-groups, randomized, controlled trial. It was conducted on 54 participants with high caries risk. Participants were randomly allocated into three groups (𝑛 = 18 for each group) according to the established regimen, in which (A1) denotes participants that were exposed to regimen with herbal toothpaste (Himalaya complete care) and (A2) denotes group where participants used preventive regimen with fluoride-based toothpaste (Signal) and (A3) represents group used fluoride-based toothpaste (Signal) and fluoride varnish. Assessment of cariogram was done in four intervals: T0: baseline, T1: after one week, T2: after four weeks and T3: after 12 weeks. Two-way ANOVA revealed statistically significant effect of follow-up time on percentage of chances to avoid new lesions (P<0.001), but material and interaction of material and follow-up had no statistically significant effect on percentage of chances to avoid new lesions sector (P= 0.179 and P=0.548) respectively
Results: Regarding caries risk, Intergroup comparison between materials have shown no statistically significant difference within different follow up periods; baseline, 1 week, 1 month, and 3 months respectively (P = 1.0000, P = 0.4631, P = 0.5113 and P = 0.9775). Intragroup comparison within A1 or A2 or A3 have shown statistically significant difference between different follow-up periods (P < 0.0001).
Conclusion: In high caries risk patients, caries preventive regimens based on herbal toothpaste has similar clinical performance to those based on fluoride toothpaste and varnish along three months follow up.
Clinical significance: In high-caries-risk individuals, preventive regimens comprising toothpastes have a favorable impact on caries prevention