الفهرس 
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Abstract
Inflammatory disease lesions (open and closing comedones), erythematous (papules, pustules, and lumps), and scarring of varied degrees are all symptoms of acne vulgaris (AV), a chronic illness of the pilosebaceous unit.
Type III collagen, a fibrillar collagen found in abundance in the skin and a multitude of internal organs, is synthesised and deposited in part by a peptide known as such amino-terminal peptide of class Iii fibrin (PIIINP.( Systemic illnesses like systemic sclerosis, which cause tissue fibrosis and severe scarring, are characterised by elevated levels of type III collagen.
By using immune-histological and real-time quantitative PCR methods, researchers have shown that inflammatory acne lesions stimulate the production of type III procollagen. Serum PIIINP may also be a measure for the extent of skin fibrosis and the potential for more severe fibrotic skin responses after scar repair.
The purpose of this investigation was to compare serum PIIINP levels between patients with acne vulgaris (of varying severity), acne scars, and a normal healthy control group. Seventy-five people aged 18 and above who were patients at Minia University Hospital’s Dermatology Outpatient Clinic participated in the study. Between the months of January and November of 2022, the research was conducted.
Those who were healthy enough to participate were split into two groups after researchers ruled out anything that may alter their blood PIIINP levels. The first set of people are the patients, who may be further broken down into four categories (comedonal , papulo-pustular , nodulo-cystic acne and acne scar ,each subgroup including fifteen patients.) And in the second group, which served as a control, were fifteen acne-free, adult men and girls.
Each person had two millilitres of blood collected from a vein so that their serum PIIINP levels could be measured. In this experiment, we used a Human procollagen type III ELISA Kit from BT LAB (Bioassay Technology Laboratory), China, and a Huma reader 3700 (Germany) to analyse the results.
The present investigation found no association between serum PIIINP and demographic variables as age, sex, or illness duration.
Serum PIIINP was significantly different between individuals with inflammatory acne (papulopustular or nodulocystic acne) and healthy controls. In contrast, serum PIIINP levels did not vary significantly between the way that contributes acne group and the control group.
Papulopustlar, nodulocystic, and acne scar patients all differed significantly from the control group. In contrast, the comedonal acne sample showed no statistically significant differences. And when we compared each of the groups we analysed to the others, we discovered that there were substantial variances across the board.
There was no statistically significant difference between any of the four patient groups (I,II,III,and IV) and there was no difference between either of the two groups, however the difference in serum PIIINP here between level 1 and comedonal acne communities was close to clinical significance.
This is the only research we are aware of to examine serum PIIINP in individuals with both distinct forms of acne and acne scars.