الفهرس 
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Abstract
This retrospective study included 50 female patients with early stage (T1-2 N0-1 M0) breast cancer who underwent breast conservative surgery .All patients received adjuvant radiotherapy at the radiotherapy department of South Egypt cancer institute (SECI), Assuit University, Egypt, between 2013 and 2016. All patients received post-operative chemotherapy then adjuvant whole breast radiotherapy (42.5GY/16 fractions) with once weekly concomitant photon boost of 1 GY for 3 weeks (total boost dose 3GY) with whole radiotherapy schedule period of 16 days (3 weeks).The patients were followed up for 60 months.Radiation toxicity locally, on the pulmonary function and on the heart function, local control, disease free survival and the overall survival were evaluated in those patients over 5 years The 5 years DFS was 94% and the local recurrence 2%, distant metastasis 4%, and 5 years OAS was 96% showing promising DFS and good local control Regarding skin toxicity, most of cases developed grade 1, 2 toxicity with no Grade 3 toxicity, radiation schedule was done without attenuation of the radiation dose or any reported interruptions Cosmetic outcome was Excellent or good in most of cases, with few poor and fair outcomes.Limitations of our study Small number of patients, relatively short period of follow upSo, Further research is required to demonstrate the efficacy of this schedule as an alternative option to standard sequential boost techniques.