الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
When it comes to female cancers, breast cancer is by far the most prevalent globally. Only around 5.6% of patients with breast cancer are younger than 40 years old, making it mostly a disease of midlife and older women. Their clinical conduct is more aggressive and they have worse outcomes than the elderly because they are less sensitive to hormones and have greater expressions of humans epidermal growth factor 2.
Several variables, both prognostic and predictive, influence how long a breast cancer patient lives after diagnosis. Numerous research on the prognostic and predictive importance of various clinicopathological and molecular factors in breast cancer have been conducted around the globe. The purpose of this research was to determine the effect of several variables on the overall survival of people with breast cancer in the Minia governorate in Upper Egypt.
from 2017 to 2021, this retrospective study looked at the correlation between hormonal manipulation, age at first marriage, consanguinity, tumor site, tumor grade, tumor size, normal tissue status, molecular classification (ER, PR, HER2 neu hopeful, Triple negative, basal like), KI67, and overall survival for young women with breast cancer in our community.
Those under the age of 40 who were diagnosed with a primary breast cancer that was confirmed by pathology.
The TNM Staging Method (according to American Joint Committee on Cancer AJCC 2017).
The incidence rate was 10% among young women, or 279 out of a total of 2760 cases.
In conclusion, there was an increase among the number of instances of breast cancer diagnosed in women aged 30 to 40. Our patients’ families accounted for 10.8% of the total. Of our patients, 91% had infiltrating ductal carcinoma. Our patients had a Grade II severity rate of 82.4%. Sixty-two percent (64%) of those with a positive ER, 68.1% with a positive PR, 28% with a positive HER2; 43.3% with a KI67 of less than 20%; 56.6% with a KI67 of more than 20%. Over eighty-five percent of patients had a negative response to ovulation induction, whereas only eighteen percent had a positive response; most instances were in stage II with a nodal status of N1 (45.9%(
Overall survival was not significantly affected by molecular subtype, stage, or nodal status, but was affected by a ki-67 percentage of 20% or below.
In conclusion, our research has shown a few high-risk subsets for developing breast cancer. They should be given top attention in whatever screening or preventative measures that are implemented. A bigger, multicenter investigation is needed to validate these findings before they can be extrapolated to everyone Egyptian women.
Especially in poor and middle-income nations, infrastructure should be put in place to facilitate early diagnosis and treatment.
When caring for young women diagnosed with breast cancer, it is important to consider their emotional well-being as well as their sexual and reproductive health.