الفهرس 
AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized by a progressive accumulation of functionally incompetent lymphocytes. CLL primarily affects elderly patients, with a median age of 72 years at time of diagnosis, the disease is more prevalent in men than in women, with a ratio of 1.6:1. chronic Lymphocytic Leukemia (CLL) is a monoclonal B-cell lymphoid leukemia characterized by the accumulation of phenotypically mature but immunologically incompetent malignant cells in the peripheral blood, bone marrow and lymphatic tissues like lymph nodes, spleen and liver. It is a clinical and molecular heterogeneous disease that is still incurable despite the important bio-molecular advances that occurred over the past few decades. Most patients are asymptomatic and are diagnosed either incidentally during routine laboratory check-up or following the evaluation of lymphadenopathy or splenomegaly. The relation between chronic inflammation and increased risk of both cancer and CVD has been well-established; it is known that chronic inflammation may have a role in the development of CLL. Many studies reported that clonal hematopoiesis had a strong association with the development of atherosclerosis, but it is still unclear whether CLL could promote the progress of atherosclerosis and CVD. Recent studies showed an increase in CVDs among patients suffering from different malignancies. Atherosclerosis is a slowly progressive disease characterized by hardening and narrowing of arteries due to accumulation of lipids and remodeling of extracellular matrix. It is an inflammatory process, and both innate and adaptive immune systems play a role in all of its stages, including formation and progression of fibro fatty lesion and final complications. Clinical presentation of ASCVD ranges from acute coronary syndrome to a history of myocardial infarction, stable or unstable angina, coronary or other arterial revascularization, stroke, transient ischemic attack, or peripheral arterial disease, which is assumed to be of an atherosclerotic origin. The aim of study was to evaluate the prevalence of cardiovascular disease risk in Egyptian patients with chronic lymphocytic leukemia (CLL), and their clinical & molecular correlations. This study was conducted on thirty (30) number of newly-diagnosed non-treated CLL adults (group 1) & healthy, age & sex -matched control subjects (group 2), selected from outpatients & inpatients of (Hematology Unit of Menoufia University Hospital).