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Abstract
Background: Growing evidence supports the notion that the onset of tumorigenesis could occur through cancer stem cells (CSCs). These tumor cells show low proliferative rates, high self-renewal capacity, propensity to differentiate into active proliferating tumor cells & resistance to chemoradiotherapy thus, possibly causing local recurrences & metastasis formation despite treatment. CD44 has been used as a marker to isolate CSCs from colorectal carcinoma (CRC). Objective: To investigate the immunohistochemical expression of cancer stem cells marker (CD44) in CRC and correlate its expression with the clinico-pathological aspects, TNM staging and modified Dukes{u2019} classification