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Abstract
Skull base lesions especially those affect the sellar region as pituitary adenomas, craniopharyngioma and pituitary cysts could be approached by the endoscopic transsphenoidal approach which is favoured more than open approaches due to its minimal invasiveness. But, the resultant sellar defect needs to be be reconstructed to form a tight barrier separating the nasal cavity from the brain. Methodlogy:A systematic review and meta-analysis is done to evaluate all articles puplished from aprill 1995 till 2014 and concerned with reconstruction of the sella after endoscopic transsphenoidal pituitary surgery with evaluation of post operative CSF leak and results were analysed with REVMAN 5 a metaanalytic software. Results:No one of the three methods of sellar reconstruction is statiscally significant which is due to low number of the patients. But the nasoseptal flap shows the trend to be better than the other two methods