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Abstract
Multidrug resistant Pseudomonas is one of the rapidly spreading bacteria causing infections with serious outcomes due to limited therapeutic options. Rapid spread of multidrug resistant bacteria (MDR) has become an emerging threat and a matter of concern worldwide.Our work aimed to screen for carbapenem resistance in 250 isolates of MDR Pseudomonas, evaluate the synergistic effect of Ý-lactam and aminoglycoside combination by using E-test in 50 selected carbapenem resistant MDR Pseudomonas isolates and investigate the role of plasmid transfer in spread of resistance.The distribution of the MDR Pseudomonas showed that the majority were encountered from ICU (47.6%) compared to inpatient wards (43.2%). Among different samples showed that the highest prevalence were in sputum (46.8%), followed by urine (26.8%), pus (21.6%) while the samples with the lowest prevalence were blood (4%) and ear discharge (2.8%)