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Abstract Stomatitis has been shown to occur closer to fourty percent in solid tumor children receiving chemotherapy. Cryotherapy is an alternative method of preventing stomatitis associated with chemotherapeutic drugs. This study aimed to evaluate the effect of oral cryotherapy on the occurrence of stomatitis induced by chemotherapy among children with bone tumors. A quasi-experimental design was utilized on a convenient sample of sixty children with bone tumors, thirty of them followed the hospital routine care (control group) and other thirty sucked ice cubes (study group) before inducing chemotherapy session for five minutes to half an hour during session and thirty five minutes after session. Both groups were treated with the same chemotherapeutic drugs protocol which included Adriamycin and Methotrexate |