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Abstract
In this study believed that PONV is multifactorial in origin, with a reported incidence ranging from 23% to 73%. Multimodal approach for PONV constitutes both pharmacological and non-pharmacological therapies.This is randomized, controlled, double - blind study was designed to explore the possible effects of oral gabapentin as premedication on the incidence and severity of PONV and on the recovery profile of pediatric patients undergoing adenotonsillectomy. We studied 140 patients undergoing adenotonsillectomy randomized to oral gabapentin 16mg / kg (n = 70) or placebo (n = 70). Oral premedication was given 2 hours before induction of sevoflurane anesthesia. The use of oral gabapentin as premedication in pediatric patients undergoing adenotonsillectomies under sevoflurane anesthesia reduced the incidence of PONV and emergence agitation in the early postoperative period