الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
The objective of the present investigation was to develop and characterize self-nanoemulsifying drug delivery system of sertraline hydrochloride (SNEDDS). Sertraline hydrochloride is a poorly water soluble drug used for the treatment of depression of the selective serotonin reuptake inhibitor class (SSRI). Solubility of sertraline hydrochloride in various vehicles were determined, and ternary phase diagrams were constructed using a suitable oil, surfactant and cosurfactant system to find out the most efficient self- emulsification system. Capmul® and Lauroglycol® were selected as the oil phase, Tween 80 and Cremophor® as surfactant and Transcutol® as cosurfactant due to their high solublization effect. Various formulations were prepared by simply mixing followed by vortexing. These formulations were characterized by solubility of the drug in the vehicle, particle size of the dispersed emulsion, zeta potential and drug release profile. Ternary phase diagrams were used to evaluate the emulsification domain