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Abstract
This study aims to correlate immunohistochemical expression of P- cadherin and E-cadherin with pathological features of breast carcinoma in addition to correlation with estrogen and progesterone receptors status and expression of Her2-neu oncoprotein. The retrospective study was conducted on 50 cases of female patients with breast cancer, admitted to Kasr Al-Ainy hospital where their paraffin blocks and copies of their pathology reports were available (from January 2012 to December 2012). All cases were treated with modified radical mastectomy with complete dissection of axillary lymph nodes. Immunohistochemical staining for each case was conducted for both E-cadherin and P-cadherin. As regards expression of E-cadherin , 38 (76 %) cases were positive for E-cadherin (expressed), while 12 (24 %) cases were negative (not expressed). As regards expression of P-cadherin , 38 (76 %) cases were positive for P-cadherin (expressed), while 12 (24 %) cases were negative (not expressed)