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Abstract
Aim of work: In this study we aim to evaluate the level of fusion gene as well as log reduction in their level at 2 weeks after starting induction chemotherapy. Patients with chromosomsal translocations will be tested for: Transcription level at diagnosis as well as for the kinetics of transcription reduction during therapy. The findings will be correlated to the achievement of complete remission, occurrence of relapse and survival data. The final aim is to verify if the transcript level at diagnosis has an impact on outcome. Also to verify if we can detect at an early point of time, namely day 14, the response to therapy