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Abstract
OBJECTIVE: To investigate the role of Angiotensin Converting Enzyme and its (insertion/deletion) polymorphism in Egyptian ischemic stroke patients. METHODS: Case control study including 20 non- hypertensive ischemic stroke patients, 20 hypertensive ischemic stroke patients and 20 age and sex matched hypertensive control subjects. Genotyping was performed using polymerase chain reaction (PCR) method. Serum ACE levels were measured by ELISA method. RESULTS: The frequency of DD genotypes were significantly higher in stroke cases (42.5%) compared to control subjects (10%) (p=0.02). ACE serum levels in non-hypertensive stroke patients, hypertensive stroke patients, and control subjects were 51.2±6.9, 40.3±6.9 and 33.3±3.7 (IU/L) respectively, (p<0.001). Patients on ACEIs prior to their stroke had a less severe stroke on presentation and better stroke outcome after 3 months as compared by the NIHS and SSS. CONCLUSION: ACE 2DD3 genotype is a risk factor for ischemic stroke. ACE serum levels are higher in stroke patients compared to control group, and higher ACE serum levels correlates with both stroke severity and worse stroke outcome