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Abstract
This study was done to evaluate serum osteocalcin level as a marker of bone turnover in patients with beta thalassemia major. The study included 70 Egyptian children (38 males and 32 females) with thalassemia major following in hematology clinic. The study showed that ionized calcium, osteocalcin levels and Z score were mostly low, while serum phosphorus, alkaline phosphatase and ferritin levels were high. Serum osteocalcin was significantly lower in patients with abnormal bone scan. We conclude that serum osteocalcin can be used as a marker of the severity of bone disease in patients with thalassemia major