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Abstract
The present work was undertaken to evaluate the antifungal potential of ZnO and Fe2O3 nanoparticles in comparison with commercial antifungal feed additives (probiotic, propionic acid and clove oil) in inhibiting the growth of A. flavus strains that were isolated from feeds using well and disc diffusion tests. The aflatoxigenic strains required higher concentrations of metal nanoparticles than non- aflatoxigenic strains where the zone diameter of growth inhibition increased when the concentration increased and it was larger in non-aflatoxigenic than aflatoxigenic strains. The concentrations of metal nanoparticles below 25 ug/ml didn’t affect the growth of all A. flavus strains. The zones of inhibition produced by the metal nanoparticles were larger than that produced by the commercial antifungal feed additives. The aflatoxin B1 production by aflatoxigenic strains in liquid medium (YES) or on yellow corn was significantly diminished in parallel with the decline parameters in colony count of the treated aflatoxigenic strains. The field application of the above used nanoparticles and other drugs on commercial poultry feed evidenced the availability to use ZnO and Fe2O3 nanoparticles only as antifungal but their antimycotoxins effect was limited to their use as feed additives during manufacture and before exposure of feeds to fungal contamination