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Abstract
Background: Magnetite nanoparticles (MNPs) have been widely used as contrast agents and have promising approaches in cancer treatment. In the present study we used Ehrlich solid carcinoma (ESC) bearing mice to investigate MNPs antitumor activity and their effect on expression of p53 and p16 genes as an indicator for apoptotic induction in tumor tissues. Moreover, histopathological effects and DNA damage which may be induced by MNPs were investigated. Method: MNPs coated with ascorbic acid (size: 25.0 ± 5.0 nm) were synthesized by co-precipitation method and characterized. Mice were treated with 60 mg/Kg MNPs day by day; intratumorally (IT) or intraperitoneally (IP). Tumor size was measured and normal and tumor tissues were taken for subsequent analyses