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Abstract
Background: During critical illness, changes in the level of circulating hormones are a common phenomenon; these alterations are correlated with the severity of morbidity and the outcome of patients in intensive care unit (ICU) and it was found that thyroid dysfunction is associated with the mortality of patients admitted to the ICU.These alterations in thyroid hormone levels are referred to as ”non thyroidal illness syndrome” (NTIS) , which is characterized by low serum levels of free and total triiodothyronine (T3) accompanied by normal or low levels of thyroxine (T4) and thyroid-stimulating hormone (TSH).Also C-reactive protein (CRP) as a measure of overall systemic inflammation is strongly and independently associated with respiratory impairment, it appears to be major determinant of hospitalization and death risk whatever the end-stage respiratory disease