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Abstract
Background: Ventilator-Associated pneumonia (VAP) represents a major health problem in mechanically ventilated patients in intensive care units (ICUs). Aerosolized colistin could represent an adjunctive treatment to intravenous antibiotics in VAP. Objectives: To evaluate the safety and efficacy of adjunctive inhaled colistin in treatment of patients with Gram-negative VAP compared to the conventional intravenous antibiotic regimen alone. Methods: This prospective randomized controlled study was conducted from July 2013 to August 2014 at Kasr El-Aini Medical ICU. Our study included a total number of 50 cases with VAP randomly assigned into two equal groups; a study group (who received the conventional systemic IV antibiotic regimen plus adjunctive inhaled colistin) and a control group (who received the conventional systemic IV antibiotic regimen alone)