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Abstract
The ideal method for anesthetic management during ERCP varied between deep sedation and general anesthesia with preference for general anesthesia over sedation. Aim of the study: To compare the effect of propofol-dexmedetomidine versus ketamine-propofol combination in patients undergoing ERCP as regard intra-procedural hemodynamic parameters (HR and MAP), total propofol consumption and recovery criteria that involved post-procedural hemodynamic parameters (HR and MAP), post-procedural pain, PONV, cognitive dysfunction Respiratory adverse events and measurement and recording of recovery time. Material and methods: Patients ERCP, age 20-50ys old, ASA II-III, were randomly allocated in two groups each of which was 30. Group-I received dexmedetomidine loading 1æg/kg slow IV over 15min then infused at a rate of 0.5æg/kg/h by syringe pump