الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
The pathogenesis of vitiligo is complex and not yet fully understood, but it is believed to involve a combination of autoimmune, genetic, and environmental factors. Classic treatment options for vitiligo include narrow band UVB and psoralens plus UVA (PUVA). Oral steroids have been tried and reported to be effective in the treatment of vitiligo. To assess clinical efficacy of NB - UVB combined with oral steroids compared to oral steroids alone in treatment of stable vitiligo patients, as well as observe any relapse/rebound that may possibly occur following cessation of treatment. 30 patients with stable vitiligo randomized into 2 groups; group A received NB - UVB for 36 sessions with oral steroids, whilst group B received oral steroids alone for 3 months. Both groups were followed up for 3 months. Basic fibroblast growth factor (bFGF) (marker of regression) and intercellular adhesion molecule (ICAM 1) (marker of activity) tissue levels were measured by RT - PCR before and after treatment and after follow-up. Anti-melanocyte antibodies (AMA) (marker of activity) detection in patients’ sera was done using cellular eliza before and after treatment and after follow up