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Abstract
Mycosis fungoides is the most common form of CTCL and accounts for around 60% of new cases. Angiogenesis is a highly ordered process required for the normal remodeling of the primary vascular plexus formed during vasculogenesis. Angiogenesis is involved in the development and progression of pathogenic processes in a variety of disorders and Angiogenesis plays a critical role in solid tumor development and metastasis. Evaluation of vascular pattern in mycosis fungoides and if such pattern would be due to vasodilatation or angiogenesis. Twenty five patients with MF and twenty age and sex matched healthy controls were enrolled in the study. The MF lesions were evaluated by dermoscopy and skin biopsy was taken from all participants. Immunohistochemical (IHC) staining for CD34 was done for the specimen. The total number of blood vessels positive for CD34 (9.1 ± 2.7) and endothelial buds (10.8 ± 4.1) were significantly higher in MF patients than that of controls, (P = 0.000). Dermoscopic evaluation showed that MF exhibts a characteristic dermoscopic pattern, where the dotted pattern of blood vessels was the most frequently encountered pattern in the MF lesions followed by the linear pattern