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Abstract
The present study aimed to assess some pharmacological activities of Commiphora molmol extract (CME), to detect its bioactive chemical constituents and to determine its acute oral toxicity. The safety of CME was tested by estimation of the acute oral LD50 in mice. Tests for the presence of alkaloids, saponins, glycosides, tannins, resins, sterol and/or triterpenes and flavonoids in CME were carried out using standard procedures. The effect of CME against Clostridium perfringens experimental infection with 109 CFU in chickens was performed. The antidiarrheal effect was studied using both castor oil- induced diarrhea in rats and charcoal meal tests in mice. The effect of CME on isolated rabbit’s duodenum was also tested. The antinociceptive activity was examined using both acetic acid (chemical)-induced abdominal writhing and radiant heat (thermal) tail flick tests in mice. The anti-inflammatory effect was studied using formalin-induced edema and swelling in rat’s paw