الفهرس 
A pharmaceutical study on nanosizing for the delivery of certain anti-inflammatory drugs
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Abstract
Piroxicam and ketoprofen are non-steroidal anti-inflammatory drugs with potent analgesic activity. Suppositories were proposed, to avoid any side effects resulting from oral dosage forms such as gastrointestinal irritation or bowel disturbance. Therefore, affording patient compliance, and to obtain enhanced therapeutic effect, in addition they are the most suitable dosage forms for children and elderly patients. However formulation of suppositories is a challenging task as this needs the accurate choice of the most suitable suppository bases that greatly affect the release of drug to realize an excellent therapeutic effect. Solid dispersion nanoparticle systems (SDNs) of drugs with different polymers and excipients were prepared to enhance the dissolution rate of drugs from their solid dispersion systems. Synthetic polymers have been used in these preparations. SDN were formulated with different suppository bases representing different classes to obtain various formulae that may guarantee good drug release. Stability studies were performed on the most promising formulae. Accordingly, for these reasons, the present work was divided into three chapters aiming at the preparation and evaluation of different formulae of piroxicam and ketoprofen solid dispersion nanoparticles(PX-SDN and KP-SDN) using different drug carriers, formulation and evaluation of suppository based PX-SDN and KP-SDN and finally accelerated stability study of the selected suppository formulae