الفهرس 
Association Between MMP-9, MMP-3 Polymorphisms And Risk of Myocardial Infarction
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Abstract
Myocardial infarction is caused by several inherited and acquired risk factors that predispose to the development of atherosclerotic lesions and plaque rupture.This rupture of an atherosclerotic plaque is a major event in the pathogenesis of an acute myocardial infarction (AMI). MMP-9 (gelatinase B) might play an important role in matrix degradation and the subsequent rupture of the atherosclerotic plaques. A functional single nucleotide polymorphism in the MMP-9 promoter, with a cytosine to thymidine transition at position -1562, was found. The T allele had a higher promoter activity than the C allele, and was associated with an elevation in both the levels of MMP-9 expression level and serum MMP-9 in humans and an association of a SNP in the MMP-9 promoter with coronary artery disease and risk of myocardial infarction lesions