الفهرس 
Pharmacological interaction between some antidiabetic drugs and some fluoroquinolone antibiotics in diabetic experimental animals
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Abstract
Disturbance in glucose homeostasis is one of the serious outcomes of using fluoroquinolones in diabetes. The study aimed to assess the risk of severe hypoglycemia and oxidative stress among diabetic rats receiving ciprofloxacin or levofloxacin with glimepiride and / or rosiglitazone and to determine the involvement of calcium channels in their actions. Male wistar rats were classified into 13 groups. The 1st group served as control animals; the remaining rats were rendered diabetic by streptozotocin (50 mg / kg; i.p.). group II received saline (diabetic control), groups III - XIII received glimepiride (0.5 mg/ kg; p.o.), rosiglitazone (4 mg / kg; i.p.), ciprofloxacin (40 mg / kg; i.p.) or levofloxacin (50 mg / kg; i.p.) alone or in combinations, daily for two weeks. Blood and liver samples were collected for estimation of blood lactate dehydrogenase and superoxide dismutase activities and levels of glucose, insulin, lipid peroxides and reduced glutathione, as well as liver glycogen content. In another experiment, samples of pancreas islets were incubated with 100æM of ciprofloxacin or levofloxacin, with or without 50 mM verapamil, at 3mM or 16.7m M glucose for 1 h to assess their effects on insulin release