الفهرس 
A pharmaceutical study on certain ototopical drug delivery systems used in the treatment of otitis
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Abstract
Ciprofloxacin is a synthetic fluoroquinolone antibiotic that has been used for systemic treatment of otitis media in adults. It was approved for topical treatment of otorrhea in children with tympanostomy tubes. The aim of this thesis was to enhance the local non -invasive delivery of ciprofloxacin to the middle ear across an intact tympanic membrane (TM) in an attempt to treat acute otitis media (AOM) ototopically. In order to achieve this goal, ciprofloxacin nano-transfersomal vesicles were prepared by thin film hydration (TFH) technique, using several edge activators (EAs) of varying hydrophilic - lipophilic balance (HLB) values at phosphatidylcholine (PC): EA molar ratio of 5 : 1. A full factorial design was employed for the optimization of formulation variables using design - expert® software. According to the desirability criterion, formula SC7, composed of PC and sodium cholate at the molar ratio of 5: 1, had the highest desirability value and thus, it was selected as an optimal formulation. In addition; ciprofloxacin - loaded spanlastics were prepared by TFH technique using several EAs at span 60 : EA weight ratio of 8:2