الفهرس 
Genetic and radiological biomarkers of cognitive impairment in parkinson’s disease
TABLE OF CONTENTSOnly 14 pages are availabe for public view
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Abstract
Cognitive impairment in parkinson’s disease (PD) has been clearly reported in the medical literature. The exact pattern of this impairment and its biomarkers are still subjects of considerable controversy. To explore the cognitive profile of patients with PD, correlate such profile with the macro and microstructural changes in the brain, evaluate the role of P300 in assessment of cognitive function in PD, and study the role of the genetic factor in the development of cognitive impairment in PD. The study was conducted on 40 patients with PD and 20 controls. selected PD patients were submitted to evaluation of motor symptoms and psychiatric manifestations using H and Y staging and UPDRS, assessment of cognitive function using PD - cognitive rating scale (PD - CRS), assessment of global brain atrophy using MRI, assessment of microstructural changes in BG, thalamus, hippocampus and prefrontal white matter using diffusion tensor imaging, measurement of P300 latency, and genotyping for GBA (L444P) mutation and BDNF (Val66Met) polymorphism