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Abstract
The comparative study of the atheroprotective effect of nicorandil in adose of 2 mg/kg/day versus atorvastatin in a dose of 10 mg/kg/day orally was carried out on high fat/high cholesterol diet (HF / HCD) induced atherosclerosis in rats as a model. The degree of protection was assessed biochemically by measuring variations in serum total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL - C), very low density lipoproteins-cholesterol (VLDL - C), atherogenic index (AI) along with superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA) and pharmacologically by estimating endothelial vascular reactivity on isolated aotic rings in rats, arterial systolic blood pressure and ECG changes including heart rate, P wave amplitude, PR interval, QRS duration, ST segment and T wave and histopathologically through measuring aortic wall thickness and atherosclerosis scoring system