الفهرس 
Study of serum hepcidin as a diagnostic tool of iron overload in Egyptian children with beta - thalassemia major and intermedia
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Abstract
Iron homeostasis proved to be regulated by hepatic peptide hormone ”Hepcidin”. Iron homeostasis is disturbed in beta - thalassemia and results in iron overload with or without transfusion dependence. To investigate serum hepcidin level and its potential usefulness in the diagnosis of iron overload in children with beta thalassemia major and intermedia as well as to assess the relationship between hepcidin level and various clinical and laboratory characteristics of recruited patients. A prospective study conducted at the Hematology clinic, elmonira children’s Hospital, Cairo University. Thirty thalassemia intermedia (TI group), 30 thalassemia major (TM group) and 60 healthy - age and sex- matched subjects were enrolled. All patients were subjected to history taking and complete physical examination. Complete blood count, liver function tests, serum bilirubin (total, direct), serum ferritin and serum hepcidin level was measured by human hepcidin, ELISA Kit