الفهرس 
Formation of soluble SaltsOnly 14 pages are availabe for public view
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Abstract
The rate-limiting stage in attaining the required concentration at the site of absorption is the dissolution of medicines taken orally. Additionally, a key element in influencing the drug’s bioavailability is the rate of dissolution. Pharmaceutical companies have recently focused on creating medicinal formulations that can be taken orally. Oral medication delivery is often hindered by issues including low water solubility and dissolution rate. Additionally, 40% of medications in development and 60% of pharmaceuticals made by direct synthesis have low solubility, which limits their bioavailability and absorption). To improve the targeted medications’ solubility and thus their bioavailability, numerous approaches were investigated. These include chemical methods (such as salt or pH Adjustment, Use of Pro-drug approach), physical methods (such as particle size reduction which includes micronization, nanosuspension formation, etc.). Other Miscellaneous Techniques such as Co-solvency technique/solvent blending technique, Co-evaporate System / Co-precipitation, etc.