الفهرس 
PsoriasisOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a common chronic autoimmune and inflammatory
skin disease in which both genetic and environmental factors have a
critical role. The most characteristic lesion is red, scaly sharply
demarcated, indurated plaques over extensor surfaces and scalp. It
affects 2.7% of the world’s population.
At the onset of psoriasis, special DCs in the epidermis and
dermis are activated among other effects, these cells produce the
messenger substances e.g TNF-α which in turn promote the
development of T helper .nss . dn n .nss n.sn n 11 eh d ,1) d(
onhL ms d .me sLot n mthe vascular and epidermal changes of
psoriasis.
Vitamin A is a lipid-soluble essential nutrient of the diet that
modulates the immune response and maintains homeostasis of
epithelial tissues and mucosa through its metabolite, retinoic acid
(RA). Both keratinocyte proliferation and differentiation are affected
by vitamin A deficiency.Deficiencies in vitamin A also have been
linked to an increased susceptibility to skin infection and
inflammation. This susceptibility has suggested an integral role for
vitamin A in promoting immune function of the skin.
The aim of this study was to evaluate the serum level of
Vitamin A in psoriasis to throw a light in its possible hypothesed role
in the etiopathogenesis of psoriasis.
This study was carried out on 45 patients diagnosed clinically
as psoriasis vulgaris. They were selected from the Outpatient
Dermatology Clinic of Menoufia University Hospital during the
period between August 2021 to November 2021.For comparison
Summary
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purposes, 45 age and sex-matched apparently healthy volunteers from
Plastic Surgery outpatient clinic were included as a control group.
After obtaining a written consent all patients were subjected to
complete history taking, dermatological examination and registration
of PASI score. Two millileters of venous blood were withdrawn from
every subject under complete aseptic condition then transferred into a
plain tube, centrifuged for 10 min at 3000 revolutions per minute
(r.p.m) then the serum was obtained and stored at - 80 ºC till
measuring of vitamin A.
The current study found that serum vitamin A level was
significanty lower in cases than controls (P value <0.001).
Vitamin A was significantly lower in males than females (P
value 0.003). There was highly significant negative correlation
between vitamin A level and PASI score among the studied patients
(P value <0.001). Vitamin A was significantly lower in
smokers.Vitamin A was significantly lower in patients with scalp,
nail, joint affection, also was significantly lower in patients with
itching and kobnerization.
The current study displayed that serum levels of Vitamin A
were decreased in patients with psoriasis vulgaris than age and gender
matched controls among the studied patients. There was highly
significant negative correlation between vitamin A level and PASI
score. Data suggested that Vitamin A may play a role in the
pathogenesis of psoriasis.