الفهرس 
Temporal Lobe EpilepsyOnly 14 pages are availabe for public view
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Abstract
Temporal lobe epilepsy (TLE) is the most frequent cause of focal and refractory seizures. Pathologic analysis shows hippocampal sclerosis in 65% of temporal lobectomy specimens from adults with TLE. The only standard treatment for seizure-free status with manifest TLE is surgical which includes amygdala-hippocampectomy. The majority of temporal lobe seizures originate in the mesial temporal structures, primarily in the hippocampus, para hippocampal gyrus and amygdala.
Recently Magnetic Resonance (MR) imaging techniques have had a very important role in precise identification of seizure focus in TLE patients as apre surgical evaluation.
Diffusion tensor imaging helps some patients by the opportunity to receive suitable treatment at the time when brain tissue is still salvageable. Patients with refractory temporal-lobe epilepsy exhibit increased diffusivity and reduced FA in a sclerotic hippocampal area, suggesting the presence of structural disorganization. There were similar findings in the region with cortical malformation where conventional MRI scans produced normal findings. These findings suggest that DTI is promising for studying localized epileptogenic lesions in patients with refractory epilepsy.
The aim of work is to compare lateralizing ability of Magnetic resonance spectroscopy and Diffusion tensor imaging in patients with temporal lobe epilepsy.
The study recruited 50 participant assigned into two groups: the first group included 25 epileptic cases and the second group included 25normal controls. group patients included 12 males (48%) and 13 females (52%) And normal controls included 15 males (60%) and 10 females (40%). Age showed a mean ± SD of 24.22 ± 9.7 years.
In our study, all the patients of cases group showed symptoms ranged from focal unaware (72%) to focal to bilateral tonic chronic (28%).
In this study, semiology is the highest and the most accurate for diagnosis of temporal lobe epilepsy, with ability of lateralization reaches to 60 %.
EEG showed the following findings among the cases (Bilateral temporal epileptic tendency to be generalized (1 case), Left fronto temporal epilepsy (1 case), Left temporal epileptic activity in 2 cases, Left temporal epileptic activity with tendency to be generalized (1 case), Right temporal epileptic activity (2 cases), Subcortical changes (1 case), and no changes in 17 cases with accuracy 66%.