الفهرس 
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Abstract
Summary
Systemic lupus erythematosus is a chronic systemic autoimmune disease with multi-organsinvolvement affection characterized by recurrent attacks of remission and exacerbation and associated with significant morbidity andmortality which predominantly affects women, especially those of reproductiveage (Cojocaru et al.,2011).
Genetic, immunological, endocrine, and environmental factors influence the loss of immunological tolerance against self-antigens leading to the formation of pathogenic autoantibodies that cause tissue damage through multiple mechanisms Angel et al., 2022).
Positive correlations have been reported between interleukin 36αlevels and SLE disease activity index (SLEDAI) (Wang et al.,2021).
The aim of this study was to assess serum level of IL-36α in SLE patientsand find its correlation with disease activity and damage.
This study was conducted on 40 clinically diagnosed SLE patients and 40 healthy controls.
The patients were diagnosed according to the 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus (Aringer et al., 2019).
All were subjected to full clinical history and examination, com-plete blood count, ESR, CRP , ANA , Anti-Ds DNA , C3, C4, liver enzymes , serum creatinine, complete urine analysis , 24 hours urinary protein, serum IL-36α by ELISA technique.
Renal Biopsy was done and classified according to the classifica-tion oflupus nephritis by the International Society of Nephrology/Renal Pathology Society (ISN/RPS) (Weening et al., 2004).
This study demonstrated the following:
• Serum IL-36α level are higher in SLE patients than healthy subjects.
• There was a statistically significant positive correlation between the interleukin 36α level :
SLEDAI&SDI
age, disease duration
fever ,oral ulcers &arthritis
renal affection,
pyuria .
ESR& CRP.
positive anti-dsDNA antibody
There was a significant negative correlation between the interleukin level 36α and complements 3 .