الفهرس 
Prognostic Role of Neutrophil Lymphocyte Ratio in Advanced Ovarian Cancer
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Abstract
Objective:
The purpose of this study was to determine the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and its dynamic change during chemotherapy in patients with advanced epithelial ovarian cancer undergoing chemotherapy.
Methods:
A retrospective analysis on patients who underwent for advanced-stage ovarian cancer at National Cancer institute between 2015 and 2018. Pretreatment NLR was evaluated before starting chemotherapy. Change in NLR was defined as the post treatment NLR value divided by the initial value. The correlation of NLR and its dynamic change with chemotherapy response score, response rate, and recurrence was analyzed.
Results:
A higher pretreatment NLR (>3.81) was associated with poor overall survival (OS), and progression-free survival (PFS). Through multivariate analysis, high pretreatment NLR was shown to be an independent parameter affecting OS and PFS. Changes in NLR during chemotherapy were better predictors of PFS than baseline NLR. Patients with increased NLR during chemotherapy showed significantly poor PFS and OS and this change was an independent predictor of PFS and OS.Conclusion:
Pretreatment NLR and its dynamic change during chemotherapy may be important prognostic factors in patients who undergo neoadjuvant chemotherapy.