الفهرس 
Hospitalization and outcome of systemic lupus erythematosus patients in an Egyptian cohort
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Abstract
This work aimed to identify prevalence, outcome, causes and risk factors of hospitalization and readmission in an Egyptian cohort of systemic lupus erythematosus (SLE) patients.
Methodology: One hundred and thirty two SLE patients, all fulfilling the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria for the classification of SLE accounting for one hundred and sixty seven hospitalizations were recruited from the outpatient clinic of the Rheumatology and Rehabilitation department, faculty of medicine, Cairo University in the period between November 2018 and November 2019. All patients included in this study were subjected to full history taking, clinical examination, laboratory investigations as well as specific investigations directed to cause of hospital admission and disease activity.Results: Our results showed that disease flare and infection were the most common causes of hospitalization among SLE patients (68.9% and 23.4% respectively). Outcome of the studied hospitalizations ranged between improvement of patients (92.2%), occurrence of complications (4.2%) and death (3%). Readmission was reported after 24% of hospitalizations. Worse outcome was associated with repeated pre-study hospital admissions (p=0.008), more cyclophosphamide (CYC)cycles use (p=0.012), higher Systemic Lupus Erythematosus Disease activity Index (SLEDAI) (p=0.013), higher SLICC damage index(p=0.000) and cardiovascular system (CVS) involvement (p=0.013).Readmission rate was higher in patients that had history of repeated hospital pre-study admissions (p=0.006), higher ESR (p=0.026), lower hemoglobin concentration (p=0.004), lower total leucocytic count (TLC)(p=0.026) and longer length of hospital stay (LOS) (p=0.044).Conclusion: Physicians should be concerned with SLEDAI, SLICC damage index, renal, CNS and CVS involvement when making diagnoses to establish appropriate treatment plans and understand prognoses.