الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 209 |  |  |
| | | from | 209 | | |
Abstract
Silicone, which is considered biologically inert, has been used in many different types of medical devices. After a silicone breast implant is placed, a mild reaction to the foreign body generally observed, followed by encapsulation.
Mammary silicone implants are one of the most widely used silicon-based medical devices. Since the introduction of silicone gelfilled breast implants, numerous reports suggested the association of silicone gel-filled breast implants with inflammatory and autoimmune phenomena.
In this hypothesis, even though modern silicone products are reputedly safe, reliable, and well-tolerated, inflammatory and immunological changes might be elicited by these foreign bodies.
Recent published studies in addition to our study demonstrated that quantitative and statistically significant increase in levels of antisilicone antibodies, anticardiolipin antibodies (IgG and IgM) and CRP as a result of human body reactions to these silicone implants without association of clinical symptoms and manifestations that could be observed.
In this study, according to C-reactive protein, findings consistent with systemic inflammation were present after 6 month post-operative. This elevation was not a circumstantial or random finding, as associations that were absent before operation, robustly suggested an integrated post-operative pro-inflammatory and procoagulatory response. This leading to relatively non-specific correlation was observed with silicone implant prosthesis after 6months assessment when perioperative trauma could no longer be involved. Acute phase reaction could signal ongoing immunogenicity of silicone and long-term monitoring is recommended.
These data demonstrated a highly significant increase of antisilicone antibody levels in patients having mammary silicone implants. This can serve as a reliable indicator of systemic exposure to silicone.
The increasing levels of anti-silicone antibody and other antibodies can be useful to physicians and surgeons who wish to assess the integrity of an implant when rupture is suspected. The high specificity of the test suggests that continuous monitoring of silicone antibody levels in implanted patients on a regular schedule could be used as a screening procedure for suspected implant failure.