الفهرس 
Neonatal sepsisOnly 14 pages are availabe for public view
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Abstract
Neonatal sepsis is the cause of substantial morbidity and mortality.
Precise estimates of neonatal sepsis burden vary by setting. Differing
estimates of disease burden have been reported from high-income countries
compared with reports from low-income and middle-income countries. The
clinical manifestations range from subclinical infection to severe
manifestations of focal or systemic disease.
The source of the pathogen might be attributed to an in-utero
infection, acquisition from maternal flora, or postnatal acquisition from the
hospital or community. The timing of exposure, inoculum size, immune
status of the infant, and virulence of the causative agent influence the
clinical expression of neonatal sepsis. Immunological immaturity of the
neonate might result in an impaired response to infectious agents. This is
especially evident in premature infants whose prolonged stays in hospital
and need for invasive procedures place them at increased risk for hospitalacquired
infections.
The present study is a prospective case control study conducted on 50
neonates with sepsis (cases) and 50 neonates without sepsis (controls), 42
out of septic neonates survived while 8 did not.
The aim of the study is to assess the ventricular function in neonates
with sepsis using tissue Doppler imaging (TDI).
Results of the statistical analysis in this study showed that there was
non-significant difference between all studied groups regarding the
demographic data (age, sex, gestational age, mode of delivery and
consanguinity).
Prematurity was a highly significant risk factor for sepsis between
cases and control groups. Also, anthropometric measurements were
Summary
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significantly different between all groups. All the clinical signs of sepsis
score were also of significantly different between cases and controls.
The laboratory investigations showed a significant difference
between cases and controls regarding all parameters of complete blood
count and hematological sepsis score. Also the results of blood culture
among cases reported higher incidence of gram negative infections rather
than gram positive ones. Staph aureus was the most common isolated
organism.
The most common complication of sepsis noted in this study were
septic shock, DIC, NEC, and multi-organ failure with high significant
difference between survived and non-survived regarding DIC.
The echocardiographic data in both cases and controls and survived
and non-survived cases were all of no significant difference. Same was
reported regarding results of tissue doppler imaging.