الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
This prospective randomised research was done on 47adult patients of both sexes between December 2021 and September 2022 at El Minia University Hospital, after clearance from the institutional ethics council of the school of medicine - Minia University (No.148:2021).
As an example of a form of MMA utilised for a particular population of patients (obese patients) having a specific operation (cholecystectomy) under a specific technique (laparoscopy), this research sought to compare the effectiveness and safety of an Erector Spinae Plane block to that of opioid-free anaesthesia (laproscopy)
A total of 300 patients participated in the study, and they were all assigned at random to one of three groups.
group A/ESP (erector spinae) block, as determined by ultrasound.
group 2 (Opioid-free anaesthetic group or group B/OFA) (Opioid free anaesthesia group).
Third, the C-group represents the status quo.
The following standards were applied to each patient:
A patient’s preoperative information includes their age, gender, body mass index, medical history, and laboratory tests (complete blood count, prothrombin time, and international normalised ratio).
Total postoperative morphine dose, Pain assessment score. Postoperative nausea and vomiting (PONV) in the PACU, the requirement for opioids after discharge, and complications following surgery.
In the study, there were no statistically significant differences between the three groups with regard to demographic data (age, sex, body mass index, operation time), however the usage of intraoperative anaesthetics was much lower in the OFA group compared to the control and ESPB groups.
The results also showed that the control group had a greater pain score than the OFA and ESPB groups, but the PONV scale was significantly lower in the OFA and ESPB groups.
Hemodynamically, all three groups were similar, however the control group had significantly higher postoperative total morphine usage compared to the other two groups.
Further, the time to rescue analgesia varied significantly across the three groups, being shortest in the control group.
Therefore, the total intraoperative anaesthetic consumption, pain score on the PONV scale, and postoperative total morphine may all be reduced with the use of OFA in laparoscopic cholecystectomy surgery.