الفهرس 
Neurogenic and Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cells and/ or Taurine in Alzheimer’s Rodent Model
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Abstract
Alzheimer’s disease (AD) is the most prevalent type of dementia characterized by its progression,
neurobehavioral and neuropathological characteristics, leading to diverse neuronal loss. Adipose-Derived
Mesenchymal Stem Cells (ADMSCs) have previously proved to have a potential role in preventing the
pathogenesis of several neurodegenerative disorders, so they are regarded as a promising new approach for
AD regenerative therapy. Taurine was found to enhance stem cell activation and propagation, yielding a
higher concentration of neural progenitors and stem cells, and aid in lessening the number of activated
microglia leading to down-regulated inflammation in vitro. The present study aimed to investigate the
possible therapeutic potential of rat ADMSCs and/or taurine in treating AD induced by Aluminium
Chloride (AlCl3) in a rat model.
It was planned to include three successive phases; induction, withdrawal, and therapeutic phases.
Fifty male Wistar rats were divided into two main groups: the control (C) group and the AD model group.
Behavioral changes, as manifested by the T-Maze experiment, were recorded. β-amyloid levels were
measured in brain homogenate and serum by ELISA. Oxidative stress marker (MDA), and antioxidant
enzymes activity (SOD and CAT) in the brain were spectrophotometrically determined. Pro-apoptotic
(p53 and Bax) and anti-apoptotic (Bcl2) gene expression in the brain were evaluated using RT-qPCR. The
histopathological alterations in brain tissues were also observed. The present study proved the potential
therapeutic ability of ADMSCs and/or taurine in alleviating the adverse pathological changes induced by
AlCl3 in the AD rat model at both physiological and molecular levels.