الفهرس | Only 14 pages are availabe for public view |
Abstract Alzheimer’s disease (AD) is the most prevalent type of dementia characterized by its progression, neurobehavioral and neuropathological characteristics, leading to diverse neuronal loss. Adipose-Derived Mesenchymal Stem Cells (ADMSCs) have previously proved to have a potential role in preventing the pathogenesis of several neurodegenerative disorders, so they are regarded as a promising new approach for AD regenerative therapy. Taurine was found to enhance stem cell activation and propagation, yielding a higher concentration of neural progenitors and stem cells, and aid in lessening the number of activated microglia leading to down-regulated inflammation in vitro. The present study aimed to investigate the possible therapeutic potential of rat ADMSCs and/or taurine in treating AD induced by Aluminium Chloride (AlCl3) in a rat model. It was planned to include three successive phases; induction, withdrawal, and therapeutic phases. Fifty male Wistar rats were divided into two main groups: the control (C) group and the AD model group. Behavioral changes, as manifested by the T-Maze experiment, were recorded. β-amyloid levels were measured in brain homogenate and serum by ELISA. Oxidative stress marker (MDA), and antioxidant enzymes activity (SOD and CAT) in the brain were spectrophotometrically determined. Pro-apoptotic (p53 and Bax) and anti-apoptotic (Bcl2) gene expression in the brain were evaluated using RT-qPCR. The histopathological alterations in brain tissues were also observed. The present study proved the potential therapeutic ability of ADMSCs and/or taurine in alleviating the adverse pathological changes induced by AlCl3 in the AD rat model at both physiological and molecular levels. |