الفهرس | Only 14 pages are availabe for public view |
Abstract To evaluate the efficacy of extremely low frequency pulsed electromagnetic field (ELF-PEMF) on oxidative stress and renal function following Paracetamol induced toxicity rat model by measuring biochemical markers of oxidant-antioxidant (superoxide dismutase, nitric oxide), lipid peroxidation (malondialdehyde) and renal function test (serum urea and creatinine levels). Methods. 22 rats of 10±2 weeks old received a single dose of Paracetamol (PC) (2 g/kg) Paramol® (500 mg/tablet) and divided into two groups randomly. group A (control group): received only PC dose and group B (PEMF group): were exposed to ELF-PEMF at four frequencies (1, 10, 20, and 40 Hz) in three series, the transition period of each pulse train is 4 min, followed by 1 min of rest, each series is performed for 20 min, for a total of 60 min/daily applications for 4 weeks. Assessment was done by measuring oxidant-antioxidant markers (superoxide dismutase, nitric oxide) lipid peroxidation (malondialdehyde) and renal function test (serum urea and creatinine), first after the induction of PC toxicity, then after 4 weeks at the end of the experiment. Results. This trial revealed a significant decrease in both oxidative markers (malondialdehyde and nitric oxide) in group B in comparing to group A, with a percentage of change (23.23%) (19.65%) in group B and (1.46%) (2.06%) in group A, respectively. A significant increase in antioxidant enzyme (superoxide dismutase) in group B in comparing to group A, with a percentage of change (19.65%) in group B and (1%) in group A, a significant decline in both serum creatinine and urea levels in group B in comparing to group A, with a percentage of change (30.54%) (17.52%) in group B and (1.9%) (1.3%) in group A, respectively. Conclusion. Pulsed electromagnetic field had an obvious improvement in antioxidation capacity and kidney function. |