الفهرس 
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Abstract
This study is a census-based analysis of medical centres throughout the country. It was conducted at El Qena University Hospital’s haematology unit/internal department of pharmacy and El Minia University’s clinical pathology laboratory.
Patients lacking ITP who were admitted to the Minia Medical University haematology unit/internal pharmacy department or saw a doctor at the university’s haematology outpatient clinic between August 2021 and September 2022 were studied.
This study aims to better understand the role of CD14 on monocytes as a sign both innate and adaptive immune responses in ITP, and the role of CD61 on platelets as a measure of plasma levels, differences in ITP severity, and duration.
Patients of two different types were included in the present study:
group 1 consisted of 16 patients with primary ITP who had not responded to immunosuppressive treatment.
group 2 consisted of 17 people with primary ITP who responded well to immunosuppressive treatment.
-We provide these services to all of our patients:
Extremely detailed historical analysis, concentrating on:
Section II-Clinical Evaluation: s
According to the ITP 2019 guidelines put forward by the American Society of Hematology (ASH), patients are evaluated based on their response to corticosteroid therapy and the length of time they have been unwell.
Patients are also evaluated based on their 2016 International Normalized Ratio (INR) blood scores.
Research in the Laboratory: Stage III
A- Normal examinations: First, a CBC, then an ANA The HCV, HBV, and HIV triple marker Four Liver Tests to Assess Health Five-Renal Function Assessment 7-TSH 6-PTT 9-PC/INR
A-Tests That Need to Be Done
CD11a quantification in flow cytometry of s(1+)CD3 T(H) cells
2 - CD19 Bcells 3 - CD3+ CD4 T-cells
Evaluation of CD14 expression on neutrophil cells by flow cytometry b.
Analysis of CD61 in neutrophils using flow cytometry.
Specifically, CD11a on CD3+(pan-)De+CD4+(CD4+ MoCD19+(B-lymphocytes) populations (B-lymphocytes).
We found that the CD11a levels on all leukocyte subpopulations were significantly higher in the refractory gang than in the rescue workers (28.514.2), (21.29.8), and (22.99.8) kitchen features solid oak Ltd. v. (21.310.5), (16.6 7.7), and (17.3 8.1), with the exception of Natriuretic peptides on CD3+, where there was a tendency for the difference to be meaningful (P = 0.08).
We also found that the mean CD11a level on individual lymphocyte subpopulations was higher in individuals with chronic illnesses compared to those with acute disorders, further supporting the idea that chronic diseases are more likely to reoccur. There was some difference, but it was negligible statistically.
There was no correlation between these variables and the severity of ITP bleeding in either refractory or responsive patients, nor was there any correlation between these variables and overall disease progression.
Our data also shows that the effectiveness (21.824.1) and scope (2.4-74.4) of cumulative neutrophils (CD14) are higher in chronically ill patients compared to those with acute or continuous diseases, and that the number of circulating immune cells is higher in refractory individuals who have a low platelet count compared to responders with an elevated white arterial cell count (21.420.1) versus (20.826.7), although this difference is not statistically significant.
We also found that the total number of neutrophils in the blood is positively correlated with the number of patients who have recurring episodes of ITP (r = 0.94, p 0.0001).
CD61 (glycoprotein IIIa), a reference marker for thrombocytopenia, was higher in G2 than in G1 (9.3 5.4 vs. 6.4 6.6), which is not statistically significant but may be clinically meaningful (p value=0.08).
The difference between the two groups in terms of bleed score was statistically significant (p value=0.05), with the resistive group having a higher average SD of ITP haemorrhage grade (4.3 3.6) and a greater incidence of potentially deadly bleeding (6.2%). Finally, we discovered that the difference between the mean Values of ITP blood scores in the acute category (75.6) and the chronic condition (2.91.5) was statistically significant (p value = 0.03).
Additionally, CD61 shows a strong and unfavourable connection with regards to ITP bleeding grades in individuals with chronic illnesses (r = -0.41) (p= = 0.04).
These results provide light on the potential role of CD61in chronic and persistent patients beyond those with an acute illness, which may improve liver function in such people and prevent life-threatening haemorrhage upon recurrence.