الفهرس 
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Abstract
Egyptian cotton leafworm, Spodoptera littoralis is a polyphagous cosmopolitan pest in Egypt causing large economic losses. It is currently controlled via the use of many agrochemicals, which have negative impacts on the ecosystem and human health. Many reports demonstrated the potential of using plant extracts secondary metabolites, as biological alternatives for controlling insect pests. The toxic effects of some Ruta angustifolia extracts as bio agents to control S. littoralis were investigated. Based on LC50 values, the acetonic extract was more effective than hexane and ethyl alcoholic ones. Three compounds were isolated from the acetonic crude extract. These compounds were evaluated for its larvicidal, biological, ultrastructure and biochemical effects on 4th instar S. littoralis larvae as compared to pyrethrin. The most prominent biological effects were presented. The ultrastructure alterations were observed in cuticle, muscle, epithelial cells and microvilli. Biochemical responses of the 4th instar S. littoralis larva has decreased in the activities of ALT, AST, chitinase, carbohydrate hydrolyzing enzymes. All treatments showed a decrease in total lipid content.