الفهرس 
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Abstract
S
everal months after the onset of the epidemic, Covid-19 remains a global health issue. Higher incidence of Covid-19 infection is seen in pregnant women, and people with compromised immune system such as elderly, and neonates. Scientific data on pregnancy, perinatal outcomes and vertical transmission of SARS-CoV-2 are constantly emerging but are still limited and unclear.
The vertical transmission of SARS-CoV-2 virus and its impact on neonatal clinical outcome has yet to be confirmed, however, several newborns have tested positive for SARS-CoV-2. Perinatal SARS-CoV-2 infection may not have the same adverse effects on neonatal outcome, including problems such as respiratory distress, thrombocytopenia accompanied by abnormal liver function, and even death in contrast to severe acute respiratory syndrome (SARS) and middle eastern respiratory syndrome.
Moreover, no severe adverse pregnancy outcomes, such as gestational hypertension, intrauterine growth restrictions, fetal distress, or stillbirth have been consistently reported in COVID 19-19 positive pregnancy cases. Additional data needs to be accumulated to examine clinical outcomes of women infected with SARS-CoV-2 and their babies.
The aim of this systematic review to study current evidence on vertical transmission rates, maternal, perinatal, and neonatal outcomes affected by COVID-19.
Material and methods: An extensive search was conducted in PubMed, Google Scholar, Embase, and Scopus databases up to September 2022. In addition, our inclusion criteria was as follows, population of Pregnant woman at any gestational age, neonates, and infants, Intervention: Pregnant woman diagnosed with COVID-19. While Comparator should be Pregnant woman without COVID-19. And Study design of Observational epidemiologic study (case–control and cohort studies).
A total of 30 articles (12 case reports, 9 case series, and 9 cohort studies) reporting data from 1810 subjects were considered eligible for inclusion in the systematic review. Maternal outcomes were Caesarean section, oxygen therapy, intubation, PROM, stillbirth, maternal mortality, and complications. While neonatal outcomes are preterm deliveries, abortion, IUGR, intubation, NICU, and neonatal mortality.
Results: As regards to Neonatal complications inn our study, Covid-19 mothers were associated with high risk regarding premature delivery and neonatal outcomes. Concerning premature delivery, 14 studies showed significant difference, higher among pregnant women with Covid-19 than without. Not only that, but 12 studies reported a premature delivery rate of 5.8% (95% CI for I2 64.96 to 85.32).
A substantial proportion of pregnant women with COVID-19 underwent oxygen therapy, 4.2% (case reports 82.2%, case series 74.2% and cohort studies 66.0%). Regarding PROM, only 0.4% of mothers experienced it during pregnancy. In addition, Maternal mortality rates showed significant association with covid-19 infection showing a higher incidence in the covid-19 infected mothers. Moreover, only 0.4% of mothers had preterm labor. While abortion showed a significant relation with covid-19 infection. In addition, NICU admission had a significant association with covid-19 infection. In contrary, IUGR didn’t show a significant relation. Not only that, but only 0.4% neonatal mortality was reported in our analysis.